The aim of this study is to provide a clinical and molecular characterization of Kelch-like Protein 11 paraneoplastic neurological syndromes through a multicenter retro-prospective collaborative study.

In particular we aim:

  • to identify cases of paraneoplastic neurological syndrome (PNS) associated with anti Kelch-like Protein 11 (KLHL-11) and to collect relevant data, to expand clinical and oncological accompaniments, and to evaluate potential prognostic factors,
  • to further validate the proposed MATCH score, for the identification of suspected KLHL-11 cases,
  • to evaluate the sensitivity and specificity of different laboratory assays for the detection of KLHL-11 antibodies,
  • to collect biological samples including PBMCs, DNA, tumor and/or CNS tissue (if available) to provide insights into the pathogenesis of the disease.